Transcultural adaptation of the “EULAR Sjögren's Syndrome Disease Activity Index (ESSDAI)” into Brazilian Portuguese

AbstractIntroductionThe EULAR Sjögren's Syndrome Disease Activity Index (ESSDAI) is an index of primary Sjögren's syndrome (PSS) systemic activity.ObjectiveTo perform the ESSDAI transcultural adaptation into Brazilian Portuguese.MethodThis was a cross-sectional study with 62 patients with PSS according to the criteria of the 2002 American-European Consensus. Six stages were conducted: conceptual, item, semantic, operational, functional, and measurement equivalences (interobserver repro- ducibility and construct validity). For the validity assessment, the ESSDAI was compared with the Physician's Global Assessment (PhGA), the Sjögren's Syndrome Disease Activity Index (SSDAI), and the Sjögren's Systemic Clinical Activity Index (SCAI). Patients were clas- sified by a specialist physician into two groups according to disease activity (active and inactive), and according to the intention-to-treat (increase in therapy and no increase in therapy). The ESSDAI was tested in these groups. The following statistical tests were used: intraclass correlation coefficient (ICC), Bland-Altman plot for reproducibility, and Spear- man's correlation coefficient (rs) and Mann-Whitney's test for validity (P < 0.05 and 95% CI).ResultsThe mean ESSDAI score was 4.95 ± 6.73. The reproducibility obtained a strong ICC of 0.89 and good agreement. When compared with other indices, it showed a strong rs with PhGA (0.83; P < 0.000), a moderate rs with SSDAI (0.658; P < 0.000) and a weak rs with the SCAI (0.411; P = 0.001). The group “active” and the group “increase in therapy” had higher ESSDAI values (P = 0.000).ConclusionThe Brazilian Portuguese version of ESSDAI was shown to be adaptable, repro- ducible, and valid for this language